Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC006
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-30 11:46
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 3x1/4 caps Madopar HBS 1 uvece New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 32 individuals with a value less than 0.64 were subsequently diagnosed with PD. That is, 76.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.64 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 36, 'TN': 27, 'TP': 6, 'FP': 3}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 9, 'TN': 10, 'TP': 33, 'FP': 20}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 19, 'TN': 9, 'TP': 23, 'FP': 21}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 8.56
timePerCircleCoV 0.278211
timePerCircleSlope -0.0504106
meanError 2.07295
tremorFreq 6.83594
tremorRelPower 26.7918
tremorGyroAmpMean 0.015128
tremorGyroAmpSlope -0.00615585
tremorGyroAmpCoV 0.3255
tremorCoordAmpMean 0.0335871
tremorCoordAmpSlope -0.00353376
tremorCoordAmpCoV 0.245224
tremorAccAmpMean 0.021944
tremorAccAmpSlope -0.00908952
tremorAccAmpCoV 0.350108
tremorPcRelVar 0.567188
tremorPcX 0.605821
tremorPcY 0.795601

Circle Segment 1

Duration 7.96 s, Accuracy Estimate 3.159 (lower is better)

Circle Segment 2

Duration 14.64 s, Accuracy Estimate 2.41 (lower is better)

Circle Segment 3

Duration 9.76 s, Accuracy Estimate 1.595 (lower is better)

Circle Segment 4

Duration 8.16 s, Accuracy Estimate 1.559 (lower is better)

Circle Segment 5

Duration 8.12 s, Accuracy Estimate 1.676 (lower is better)

Circle Segment 6

Duration 7.12 s, Accuracy Estimate 1.692 (lower is better)

Circle Segment 7

Duration 7.36 s, Accuracy Estimate 1.639 (lower is better)

Circle Segment 8

Duration 7.2 s, Accuracy Estimate 1.436 (lower is better)

Circle Segment 9

Duration 9.2 s, Accuracy Estimate 2.441 (lower is better)

Circle Segment 10

Duration 6.08 s, Accuracy Estimate 3.124 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 21.108
timePerSpiralCoV 0.12909
timePerSpiralSlope -0.0322842
meanError 2.39386
tremorFreq 5.07812
tremorRelPower 23.3965
tremorGyroAmpMean 0.0356339
tremorGyroAmpSlope 0.00292296
tremorGyroAmpCoV 0.513881
tremorCoordAmpMean 0.0514335
tremorCoordAmpSlope 0.00173077
tremorCoordAmpCoV 0.357897
tremorAccAmpMean 0.0418504
tremorAccAmpSlope 0.00184242
tremorAccAmpCoV 0.378226
tremorPcRelVar 0.688624
tremorPcX 0.829123
tremorPcY 0.559067

Spiral Segment 1

Duration 25.36 s, Accuracy Estimate 1.946 (lower is better)

Spiral Segment 2

Duration 19.72 s, Accuracy Estimate 2.602 (lower is better)

Spiral Segment 3

Duration 25.32 s, Accuracy Estimate 1.732 (lower is better)

Spiral Segment 4

Duration 23.2 s, Accuracy Estimate 2.116 (lower is better)

Spiral Segment 5

Duration 22.24 s, Accuracy Estimate 2.736 (lower is better)

Spiral Segment 6

Duration 19.36 s, Accuracy Estimate 3.109 (lower is better)

Spiral Segment 7

Duration 18.6 s, Accuracy Estimate 2.398 (lower is better)

Spiral Segment 8

Duration 19.96 s, Accuracy Estimate 2.497 (lower is better)

Spiral Segment 9

Duration 19.28 s, Accuracy Estimate 2.836 (lower is better)

Spiral Segment 10

Duration 18.04 s, Accuracy Estimate 1.966 (lower is better)

Elel

eDurationMean 0.38575
eDurationStd 0.0821002
eDurationStdnorm 0.212833
eDurationMedian 0.3925
eDurationQuartdelta 0.0975
eDurationQuartdeltanorm 0.248408
eDurationKurt 3.92171
eDurationTrenddiff -0.0275
eDurationTrendratio 0.932099
eWidthMean 3.12097
eWidthStd 0.9915
eWidthStdnorm 0.317689
eWidthMedian 2.925
eWidthQuartdelta 1.1115
eWidthQuartdeltanorm 0.38
eWidthKurt 6.54108
eWidthTrenddiff -0.1755
eWidthTrendratio 0.941176
eHeightMean 4.54253
eHeightStd 1.02851
eHeightStdnorm 0.226418
eHeightMedian 4.6215
eHeightQuartdelta 1.404
eHeightQuartdeltanorm 0.303797
eHeightKurt 2.53887
eHeightTrenddiff -0.468
eHeightTrendratio 0.902439
eAspectMean 0.699804
eAspectStd 0.180989
eAspectStdnorm 0.258628
eAspectMedian 0.704839
eAspectQuartdelta 0.234691
eAspectQuartdeltanorm 0.332972
eAspectKurt 2.45122
eAspectTrenddiff -0.0830106
eAspectTrendratio 0.89046
eSlantMean 0.0619075
eSlantStd 0.378014
eSlantStdnorm 6.10611
eSlantMedian 0.114379
eSlantQuartdelta 0.323595
eSlantQuartdeltanorm 2.82915
eSlantKurt 6.73246
eSlantTrenddiff 0.0460932
eRtopMean 0.824598
eRtopStd 0.141612
eRtopStdnorm 0.171734
eRtopMedian 0.841053
eRtopQuartdelta 0.181447
eRtopQuartdeltanorm 0.215738
eRtopKurt 3.33895
eRtopTrenddiff 0.0884742
eRbotMean 0.79467
eRbotStd 0.675034
eRbotStdnorm 0.849452
eRbotMedian 0.589474
eRbotQuartdelta 0.388577
eRbotQuartdeltanorm 0.659194
eRbotKurt 10.308
eRbotTrenddiff 0.193543
eRrightMean 0.916388
eRrightStd 0.0698942
eRrightStdnorm 0.0762714
eRrightMedian 0.914855
eRrightQuartdelta 0.0809137
eRrightQuartdeltanorm 0.0884443
eRrightKurt 4.1027
eRrightTrenddiff 0.0594746
eRleftMean 0.328479
eRleftStd 0.164131
eRleftStdnorm 0.499668
eRleftMedian 0.34216
eRleftQuartdelta 0.228862
eRleftQuartdeltanorm 0.668874
eRleftKurt 2.18799
eRleftTrenddiff -0.115747
lDurationMean 0.485882
lDurationStd 0.162879
lDurationStdnorm 0.335223
lDurationMedian 0.45
lDurationQuartdelta 0.085
lDurationQuartdeltanorm 0.188889
lDurationKurt 11.3054
lDurationTrenddiff -0.085
lDurationTrendratio 0.828283
lWidthMean 6.62426
lWidthStd 1.50964
lWidthStdnorm 0.227896
lWidthMedian 6.552
lWidthQuartdelta 1.521
lWidthQuartdeltanorm 0.232143
lWidthKurt 3.69372
lWidthTrenddiff 0.117
lWidthTrendratio 1.01786
lHeightMean 9.594
lHeightStd 2.75129
lHeightStdnorm 0.286772
lHeightMedian 8.5995
lHeightQuartdelta 2.574
lHeightQuartdeltanorm 0.29932
lHeightKurt 4.58398
lHeightTrenddiff 0.351
lHeightTrendratio 1.04167
lAspectMean 0.705206
lAspectStd 0.124018
lAspectStdnorm 0.175861
lAspectMedian 0.715319
lAspectQuartdelta 0.158595
lAspectQuartdeltanorm 0.221713
lAspectKurt 2.2289
lAspectTrenddiff 0.0263437
lAspectTrendratio 1.03783
lSlantMean 0.494847
lSlantStd 0.236798
lSlantStdnorm 0.478528
lSlantMedian 0.563966
lSlantQuartdelta 0.296455
lSlantQuartdeltanorm 0.52566
lSlantKurt 6.99671
lSlantTrenddiff 0.265252
lRtopMean 0.93462
lRtopStd 0.072359
lRtopStdnorm 0.0774208
lRtopMedian 0.954356
lRtopQuartdelta 0.0663252
lRtopQuartdeltanorm 0.0694974
lRtopKurt 11.9343
lRtopTrenddiff 0.0514043
lRbotMean 0.258231
lRbotStd 0.27599
lRbotStdnorm 1.06877
lRbotMedian 0.15155
lRbotQuartdelta 0.207681
lRbotQuartdeltanorm 1.37038
lRbotKurt 10.7519
lRbotTrenddiff -0.196429
lRrightMean 0.964112
lRrightStd 0.0490546
lRrightStdnorm 0.0508806
lRrightMedian 0.977373
lRrightQuartdelta 0.033665
lRrightQuartdeltanorm 0.0344444
lRrightKurt 10.9711
lRrightTrenddiff 0.030303
lRleftMean 0.140045
lRleftStd 0.141001
lRleftStdnorm 1.00683
lRleftMedian 0.0756167
lRleftQuartdelta 0.18643
lRleftQuartdeltanorm 2.46545
lRleftKurt 5.46298
lRleftTrenddiff -0.178551

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.785391
sumTouchScores 13.3516
meanMovementTime 1.10062
numTouches 17
undershootPercentage 0
overshootPercentage 52.9412

FITTS Long Modified

meanTouchScore 0.799445
sumTouchScores 12.7911
meanMovementTime 1.19367
numTouches 16
undershootPercentage 0
overshootPercentage 31.25

ZigZag

numZigzags 7
timePerZigzagMean 19.7543
timePerZigzagCoV 0.106945
timePerZigzagSlope 0.0128001
meanError 3.35695
tremorFreq 4.6875
tremorRelPower 20.8688
tremorGyroAmpMean 0.0692488
tremorGyroAmpSlope 0.000886398
tremorGyroAmpCoV 0.341261
tremorCoordAmpMean 0.119793
tremorCoordAmpSlope -0.00570235
tremorCoordAmpCoV 1.01489
tremorAccAmpMean 0.0776829
tremorAccAmpSlope -0.000612512
tremorAccAmpCoV 0.29743
tremorPcRelVar 0.802439
tremorPcX 0.34866
tremorPcY -0.937249

ZigZag Segment 1

Duration 20.44 s, Accuracy Estimate 3.817 (lower is better)

ZigZag Segment 2

Duration 19.88 s, Accuracy Estimate 3.329 (lower is better)

ZigZag Segment 3

Duration 19.2 s, Accuracy Estimate 3.242 (lower is better)

ZigZag Segment 4

Duration 18.44 s, Accuracy Estimate 2.37 (lower is better)

ZigZag Segment 5

Duration 16.28 s, Accuracy Estimate 3.822 (lower is better)

ZigZag Segment 6

Duration 21.04 s, Accuracy Estimate 3.138 (lower is better)

ZigZag Segment 7

Duration 23.0 s, Accuracy Estimate 3.781 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 22.24
timePerZigzagCoV 0.160491
timePerZigzagSlope -0.0618705
zigzagHeightMean 73.4579
zigzagHeightCoV 0.0156908
zigzagHeightSlope 0.00275938
meanError 0.0559791
tremorFreq 4.98047
tremorRelPower 23.8503
tremorGyroAmpMean 0.0498461
tremorGyroAmpSlope 0.000915676
tremorGyroAmpCoV 0.471602
tremorCoordAmpMean 0.0861263
tremorCoordAmpSlope 0.0010938
tremorCoordAmpCoV 0.64912
tremorAccAmpMean 0.057578
tremorAccAmpSlope -0.000452482
tremorAccAmpCoV 0.303624
tremorPcRelVar 0.713669
tremorPcX -0.423358
tremorPcY 0.905962

ZigZag Offset Segment 1

Duration 25.24 s, Accuracy Estimate 0.074 (lower is better)

ZigZag Offset Segment 2

Duration 21.28 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 3

Duration 23.2 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 4

Duration 24.96 s, Accuracy Estimate 0.064 (lower is better)

ZigZag Offset Segment 5

Duration 16.52 s, Accuracy Estimate 0.062 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.69}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.64}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7550159789479984}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8929948155775269}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5902799076172822}